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Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis
BACKGROUND: Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal...
Autores principales: | Di Gregorio, Jacopo, Sferra, Roberta, Speca, Silvia, Vetuschi, Antonella, Dubuquoy, Caroline, Desreumaux, Pierre, Pompili, Simona, Cristiano, Loredana, Gaudio, Eugenio, Flati, Vincenzo, Latella, Giovanni |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313173/ https://www.ncbi.nlm.nih.gov/pubmed/28207769 http://dx.doi.org/10.1371/journal.pone.0171093 |
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