Cargando…
Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks
Replication is not as continuous as once thought, with DNA damage frequently stalling replication forks. Aberrant repair of stressed replication forks can result in cell death or genome instability and resulting transformation to malignancy. Stressed replication forks are most commonly repaired via...
Autores principales: | Kim, Hyun-Suk, Nickoloff, Jac A., Wu, Yuehan, Williamson, Elizabeth A., Sidhu, Gurjit Singh, Reinert, Brian L., Jaiswal, Aruna S., Srinivasan, Gayathri, Patel, Bhavita, Kong, Kimi, Burma, Sandeep, Lee, Suk-Hee, Hromas, Robert A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314175/ https://www.ncbi.nlm.nih.gov/pubmed/28049724 http://dx.doi.org/10.1074/jbc.M116.758235 |
Ejemplares similares
-
EEPD1 promotes repair of oxidatively-stressed replication forks
por: Jaiswal, Aruna S, et al.
Publicado: (2023) -
The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
por: Hromas, Robert, et al.
Publicado: (2017) -
Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses
por: Sharma, Neelam, et al.
Publicado: (2020) -
EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
por: Wu, Yuehan, et al.
Publicado: (2015) -
The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart
por: Kim, Hyun-Suk, et al.
Publicado: (2014)