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Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics

Peptide Nucleic Acids (PNAs) can efficiently target DNA or RNA acting as chemical tools for gene regulation. Their backbone modification and functionalization is often used to increase the affinity for a particular sequence improving selectivity. The understanding of the trading forces that lead the...

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Detalles Bibliográficos
Autores principales: Verona, Massimiliano Donato, Verdolino, Vincenzo, Palazzesi, Ferruccio, Corradini, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314342/
https://www.ncbi.nlm.nih.gov/pubmed/28211525
http://dx.doi.org/10.1038/srep42799