Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Endothelial dysfunction is characterised by aberrant redox signalling and an inflammatory phenotype. Shear stress antagonises endothelial dysfunction by increasing nitric oxide formation, activating anti-inflammatory pathways and suppressing inflammatory pathways. The TAK1 (MAP3K7) is a key mediator...

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Detalles Bibliográficos
Autores principales: Lee, Ee Soo, Boldo, Llorenç Solé, Fernandez, Bernadette O., Feelisch, Martin, Harmsen, Martin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314358/
https://www.ncbi.nlm.nih.gov/pubmed/28209993
http://dx.doi.org/10.1038/srep42487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314358/
https://www.ncbi.nlm.nih.gov/pubmed/28209993
http://dx.doi.org/10.1038/srep42487

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