Isothiourea-catalysed enantioselective pyrrolizine synthesis: synthetic and computational studies

The catalytic enantioselective synthesis of a range of cis-pyrrolizine carboxylate derivatives with outstanding stereocontrol (14 examples, >95 : 5 dr, >98 : 2 er) through an isothiourea-catalyzed intramolecular Michael addition-lactonisation and ring-opening approach from the corresponding en...

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Detalles Bibliográficos
Autores principales: Stark, Daniel G., Williamson, Patrick, Gayner, Emma R., Musolino, Stefania F., Kerr, Ryan W. F., Taylor, James E., Slawin, Alexandra M. Z., O'Riordan, Timothy J. C., Macgregor, Stuart A., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314687/
https://www.ncbi.nlm.nih.gov/pubmed/27489030
http://dx.doi.org/10.1039/c6ob01557c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314687/
https://www.ncbi.nlm.nih.gov/pubmed/27489030
http://dx.doi.org/10.1039/c6ob01557c

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