Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation

Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT and TFB2M to melt the promoter. However, we show that TFAM has ‘post-recruitment’ roles in promoter melting and RNA synthe...

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Detalles Bibliográficos
Autores principales: Ramachandran, Aparna, Basu, Urmimala, Sultana, Shemaila, Nandakumar, Divya, Patel, Smita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314767/
https://www.ncbi.nlm.nih.gov/pubmed/27903899
http://dx.doi.org/10.1093/nar/gkw1157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314767/
https://www.ncbi.nlm.nih.gov/pubmed/27903899
http://dx.doi.org/10.1093/nar/gkw1157

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