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The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates DNA joint formation during HR, but to accomplish this task, RAD51 must be loaded onto the single-stranded DNA...
Autores principales: | Kelso, Andrew A., Goodson, Steven D., Watts, Leah E., Ledford, LeAnna L., Waldvogel, Sarah M., Diehl, J. Nathaniel, Shah, Shivani B., Say, Amanda F., White, Julie D., Sehorn, Michael G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314795/ https://www.ncbi.nlm.nih.gov/pubmed/27694622 http://dx.doi.org/10.1093/nar/gkw877 |
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