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Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism

A precise and rapid adjustment of fluxes through metabolic pathways is crucial for organisms to prevail in changing environmental conditions. Based on this reasoning, many guiding principles that govern the evolution of metabolic networks and their regulation have been uncovered. To this end, method...

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Detalles Bibliográficos
Autores principales: Ewald, Jan, Bartl, Martin, Dandekar, Thomas, Kaleta, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315294/
https://www.ncbi.nlm.nih.gov/pubmed/28212377
http://dx.doi.org/10.1371/journal.pcbi.1005371