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Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation

The kynurenine pathway of tryptophan metabolism has an important role in mediating the behavioral effects of inflammation, which has implications in understanding neuropsychiatric comorbidity and for the development of novel therapies. Inhibition of the rate-limiting enzyme, indoleamine 2,3-dioxygen...

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Detalles Bibliográficos
Autores principales: Parrott, J M, Redus, L, Santana-Coelho, D, Morales, J, Gao, X, O'Connor, J C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315555/
https://www.ncbi.nlm.nih.gov/pubmed/27754481
http://dx.doi.org/10.1038/tp.2016.200