IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes

Lithium is the prototype mood stabilizer but its mechanism is still unresolved. Two hypotheses dominate—the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the ‘inositol depletion' hypothesis), and of glycogen-synthase kinase-3....

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Detalles Bibliográficos
Autores principales: Sade, Y, Toker, L, Kara, N Z, Einat, H, Rapoport, S, Moechars, D, Berry, G T, Bersudsky, Y, Agam, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315558/
https://www.ncbi.nlm.nih.gov/pubmed/27922641
http://dx.doi.org/10.1038/tp.2016.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315558/
https://www.ncbi.nlm.nih.gov/pubmed/27922641
http://dx.doi.org/10.1038/tp.2016.217

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