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IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes
Lithium is the prototype mood stabilizer but its mechanism is still unresolved. Two hypotheses dominate—the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the ‘inositol depletion' hypothesis), and of glycogen-synthase kinase-3....
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315558/ https://www.ncbi.nlm.nih.gov/pubmed/27922641 http://dx.doi.org/10.1038/tp.2016.217 |