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Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?
Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0.75) is frequently used to scale size-related changes in plasma clearance (CL(p)) from adults to children. A systematic assessment of its applicability is undertaken for scenarios considering size-related changes with and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315734/ https://www.ncbi.nlm.nih.gov/pubmed/27510367 http://dx.doi.org/10.1007/s40262-016-0436-x |