Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

Studies on the genotoxicity of Alternaria mycotoxins focus primarily on the native compounds. Alternariol (AOH) and its methyl ether (AME) have been reported to represent substrates for cytochrome P450 enzymes, generating hydroxylated metabolites. The impact of these phase I metabolites on genotoxic...

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Detalles Bibliográficos
Autores principales: Tiessen, Christine, Ellmer, Doris, Mikula, Hannes, Pahlke, Gudrun, Warth, Benedikt, Gehrke, Helge, Zimmermann, Kristin, Heiss, Elke, Fröhlich, Johannes, Marko, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316404/
https://www.ncbi.nlm.nih.gov/pubmed/27422292
http://dx.doi.org/10.1007/s00204-016-1801-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316404/
https://www.ncbi.nlm.nih.gov/pubmed/27422292
http://dx.doi.org/10.1007/s00204-016-1801-0

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