DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (DSBs) in G1 cells with biphasic kinetics. We show that DSBs repaired with slow kinetics, including those localizing to heterochromatic regions or harboring additional lesions at the DSB site, undergo resection prior to r...

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Detalles Bibliográficos
Autores principales: Biehs, Ronja, Steinlage, Monika, Barton, Olivia, Juhász, Szilvia, Künzel, Julia, Spies, Julian, Shibata, Atsushi, Jeggo, Penny A., Löbrich, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316416/
https://www.ncbi.nlm.nih.gov/pubmed/28132842
http://dx.doi.org/10.1016/j.molcel.2016.12.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316416/
https://www.ncbi.nlm.nih.gov/pubmed/28132842
http://dx.doi.org/10.1016/j.molcel.2016.12.016

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