Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by the polyol pathway and its metabolism through fruct...

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Detalles Bibliográficos
Autores principales: Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316807/
https://www.ncbi.nlm.nih.gov/pubmed/28194018
http://dx.doi.org/10.1038/ncomms14181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316807/
https://www.ncbi.nlm.nih.gov/pubmed/28194018
http://dx.doi.org/10.1038/ncomms14181

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