Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours

Most breast cancers may have a luminal origin. TP53 is one of the most frequently mutated genes in breast cancers. However, how p53 deficiency contributes to breast tumorigenesis from luminal cells remains elusive. Here we report that induced p53 loss in Krt8(+) mammary luminal cells leads to their...

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Detalles Bibliográficos
Autores principales: Tao, Luwei, Xiang, Dongxi, Xie, Ying, Bronson, Roderick T., Li, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316831/
https://www.ncbi.nlm.nih.gov/pubmed/28194015
http://dx.doi.org/10.1038/ncomms14431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316831/
https://www.ncbi.nlm.nih.gov/pubmed/28194015
http://dx.doi.org/10.1038/ncomms14431

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