Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomez-Pastor, Rocio, Burchfiel, Eileen T., Neef, Daniel W., Jaeger, Alex M., Cabiscol, Elisa, McKinstry, Spencer U., Doss, Argenia, Aballay, Alejandro, Lo, Donald C., Akimov, Sergey S., Ross, Christopher A., Eroglu, Cagla, Thiele, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316841/
https://www.ncbi.nlm.nih.gov/pubmed/28194040
http://dx.doi.org/10.1038/ncomms14405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316841/
https://www.ncbi.nlm.nih.gov/pubmed/28194040
http://dx.doi.org/10.1038/ncomms14405

Ejemplares similares