Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

ETS transcription factors are commonly deregulated in cancer by chromosomal translocation, overexpression or post-translational modification to induce gene expression programs essential in tumorigenicity. Targeted destruction of these proteins may have therapeutic impact. Here we report that Ets-1 d...

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Detalles Bibliográficos
Autores principales: Potu, Harish, Peterson, Luke F., Kandarpa, Malathi, Pal, Anupama, Sun, Hanshi, Durham, Alison, Harms, Paul W., Hollenhorst, Peter C., Eskiocak, Ugur, Talpaz, Moshe, Donato, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316860/
https://www.ncbi.nlm.nih.gov/pubmed/28198367
http://dx.doi.org/10.1038/ncomms14449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316860/
https://www.ncbi.nlm.nih.gov/pubmed/28198367
http://dx.doi.org/10.1038/ncomms14449

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