microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genetic deletion of the miR-17∼92 cluster inhibits cyst...

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Detalles Bibliográficos
Autores principales: Hajarnis, Sachin, Lakhia, Ronak, Yheskel, Matanel, Williams, Darren, Sorourian, Mehran, Liu, Xueqing, Aboudehen, Karam, Zhang, Shanrong, Kersjes, Kara, Galasso, Ryan, Li, Jian, Kaimal, Vivek, Lockton, Steven, Davis, Scott, Flaten, Andrea, Johnson, Joshua A., Holland, William L., Kusminski, Christine M., Scherer, Philipp E., Harris, Peter C., Trudel, Marie, Wallace, Darren P., Igarashi, Peter, Lee, Edmund C., Androsavich, John R., Patel, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316862/
https://www.ncbi.nlm.nih.gov/pubmed/28205547
http://dx.doi.org/10.1038/ncomms14395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316862/
https://www.ncbi.nlm.nih.gov/pubmed/28205547
http://dx.doi.org/10.1038/ncomms14395

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