A combination of mutational and computational scanning guides the design of an artificial ligand-binding controlled lipase

Allostery, i.e. the control of enzyme activity by a small molecule at a location distant from the enzyme’s active site, represents a mechanism essential for sustaining life. The rational design of allostery is a non-trivial task but can be achieved by fusion of a sensory domain, which responds to en...

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Detalles Bibliográficos
Autores principales: Kaschner, Marco, Schillinger, Oliver, Fettweiss, Timo, Nutschel, Christina, Krause, Frank, Fulton, Alexander, Strodel, Birgit, Stadler, Andreas, Jaeger, Karl-Erich, Krauss, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316958/
https://www.ncbi.nlm.nih.gov/pubmed/28218303
http://dx.doi.org/10.1038/srep42592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316958/
https://www.ncbi.nlm.nih.gov/pubmed/28218303
http://dx.doi.org/10.1038/srep42592

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