The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation

SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic profil...

Descripción completa

Detalles Bibliográficos
Autores principales: Paul, Indranil, Batth, Tanveer S., Iglesias-Gato, Diego, Al-Araimi, Amna, Al-Haddabi, Ibrahim, Alkharusi, Amira, Norstedt, Gunnar, Olsen, Jesper V., Zadjali, Fahad, Flores-Morales, Amilcar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316984/
https://www.ncbi.nlm.nih.gov/pubmed/28216640
http://dx.doi.org/10.1038/srep42800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316984/
https://www.ncbi.nlm.nih.gov/pubmed/28216640
http://dx.doi.org/10.1038/srep42800

Ejemplares similares