Mechanistic Investigation on ROS Resistance of Phosphorothioated DNA

Phosphorothioated DNA (PT-DNA) exhibits a mild anti-oxidant property both in vivo and in vitro. It was found that 8-OHdG and ROS levels were significantly lower in dnd+ (i.e. S(+)) E. coli., compared to a dnd− (i.e. S(−)) strain. Furthermore, different from traditional antioxidants, phosphorothioate...

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Detalles Bibliográficos
Autores principales: Wu, Tingting, Huang, Qiang, Wang, Xiao-Lei, Shi, Ting, Bai, Linquan, Liang, Jingdan, Wang, Zhijun, Deng, Zixin, Zhao, Yi-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316992/
https://www.ncbi.nlm.nih.gov/pubmed/28216673
http://dx.doi.org/10.1038/srep42823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316992/
https://www.ncbi.nlm.nih.gov/pubmed/28216673
http://dx.doi.org/10.1038/srep42823

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