Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization

Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting memb...

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Detalles Bibliográficos
Autores principales: Degani-Katzav, Nurit, Klein, Moshe, Har-Even, Moran, Gortler, Revital, Tobi, Ruthi, Paas, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317004/
https://www.ncbi.nlm.nih.gov/pubmed/28218274
http://dx.doi.org/10.1038/srep42481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317004/
https://www.ncbi.nlm.nih.gov/pubmed/28218274
http://dx.doi.org/10.1038/srep42481

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