Ex vivo(18)O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

BACKGROUND: Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cerebrospinal fluid (...

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Detalles Bibliográficos
Autores principales: Portelius, Erik, Mattsson, Niklas, Pannee, Josef, Zetterberg, Henrik, Gisslén, Magnus, Vanderstichele, Hugo, Gkanatsiou, Eleni, Crespi, Gabriela A. N., Parker, Michael W., Miles, Luke A., Gobom, Johan, Blennow, Kaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317049/
https://www.ncbi.nlm.nih.gov/pubmed/28219449
http://dx.doi.org/10.1186/s13024-017-0152-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317049/
https://www.ncbi.nlm.nih.gov/pubmed/28219449
http://dx.doi.org/10.1186/s13024-017-0152-5

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