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S 38093, a histamine H(3) antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice

Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H(3) receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unclear whether these ligands have effects on AHN....

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Detalles Bibliográficos
Autores principales: Guilloux, Jean-Philippe, Samuels, Benjamin A., Mendez-David, Indira, Hu, Alice, Levinstein, Marjorie, Faye, Charlène, Mekiri, Maryam, Mocaer, Elisabeth, Gardier, Alain M., Hen, René, Sors, Aurore, David, Denis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317168/
https://www.ncbi.nlm.nih.gov/pubmed/28218311
http://dx.doi.org/10.1038/srep42946