Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes

Metronidazole (MTDZ), the drug of choice for the treatment of protozoal infections such as luminal amebiasis, is highly susceptible to colonic metabolism, which may hinder its conversion from a colon-specific prodrug to an effective anti-amebic agent targeting the entire large intestine. Thus, in an...

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Detalles Bibliográficos
Autores principales: Kim, Wooseong, Yang, Yejin, Kim, Dohoon, Jeong, Seongkeun, Yoo, Jin-Wook, Yoon, Jeong-Hyun, Jung, Yunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317261/
https://www.ncbi.nlm.nih.gov/pubmed/28243064
http://dx.doi.org/10.2147/DDDT.S129922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317261/
https://www.ncbi.nlm.nih.gov/pubmed/28243064
http://dx.doi.org/10.2147/DDDT.S129922

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