Safety Profile Based on Concordance of Nonclinical Toxicity and Clinical Adverse Drug Reactions for Blood Cancer Drugs Approved in Japan

BACKGROUND: In drug development, animal toxicology data are very important for the evaluation of clinical safety. We quantitatively assessed the safety profiles of blood cancer drugs approved in Japan from category I (high) to V (low). We examined the ratios of drug exposure in animals at the no obs...

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Detalles Bibliográficos
Autores principales: Kubota, Sachie, Saito, Kazuyuki, Ono, Shunsuke, Kodama, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318328/
https://www.ncbi.nlm.nih.gov/pubmed/27995532
http://dx.doi.org/10.1007/s40268-016-0160-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318328/
https://www.ncbi.nlm.nih.gov/pubmed/27995532
http://dx.doi.org/10.1007/s40268-016-0160-x

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