Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor

P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) are expressed in the intestine and are associated with drug absorption and metabolism. Pregnane X receptor (PXR) is the key molecule that regulates the expression of P-gp and CYP3A4. Given that PXR activity is regulated by a variety of compounds...

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Detalles Bibliográficos
Autores principales: Okada, Naoto, Murakami, Aki, Urushizaki, Shiori, Matsuda, Misa, Kawazoe, Kazuyoshi, Ishizawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318391/
https://www.ncbi.nlm.nih.gov/pubmed/28270768
http://dx.doi.org/10.3389/fphar.2017.00084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318391/
https://www.ncbi.nlm.nih.gov/pubmed/28270768
http://dx.doi.org/10.3389/fphar.2017.00084

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