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Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor

P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) are expressed in the intestine and are associated with drug absorption and metabolism. Pregnane X receptor (PXR) is the key molecule that regulates the expression of P-gp and CYP3A4. Given that PXR activity is regulated by a variety of compounds...

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Detalles Bibliográficos
Autores principales:	Okada, Naoto, Murakami, Aki, Urushizaki, Shiori, Matsuda, Misa, Kawazoe, Kazuyoshi, Ishizawa, Keisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318391/ https://www.ncbi.nlm.nih.gov/pubmed/28270768 http://dx.doi.org/10.3389/fphar.2017.00084

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