Cargando…

Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies

OBJECTIVES: Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avery, Kerry N L, Williamson, Paula R, Gamble, Carrol, O'Connell Francischetto, Elaine, Metcalfe, Chris, Davidson, Peter, Williams, Hywel, Blazeby, Jane M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Health Services Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318608/ https://www.ncbi.nlm.nih.gov/pubmed/28213598 http://dx.doi.org/10.1136/bmjopen-2016-013537

Ejemplares similares

Optimising the design of internal pilot work to inform efficient randomised controlled trials: issues to consider when developing progression criteria
por: Avery, Kerry, et al.
Publicado: (2015)

Optimising the design and evaluation of pilot work to inform the main trial: a review of current evidence and consideration of future practices
por: O'Connell Francischetto, Elaine, et al.
Publicado: (2013)

How can pilot work optimally inform surgical RCTs? A review of current evidence
por: Fairhurst, Katherine, et al.
Publicado: (2015)

Assessment of patient-reported adverse events after discharge from hospital in RCTs in gastrointestinal cancer surgery: is there sufficient coverage in existing EORTC questionnaires?
por: Avery, Kerry, et al.
Publicado: (2015)

A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials
por: Rosala-Hallas, Anna, et al.
Publicado: (2019)

Development of a ‘universal-reporter’ outcome measure (UROM) for patient and healthcare professional completion: a mixed methods study demonstrating a novel concept for optimal questionnaire design
por: Macefield, Rhiannon, et al.
Publicado: (2019)

Selective reporting of outcomes in randomised controlled trials in systematic reviews of cystic fibrosis
por: Dwan, Kerry, et al.
Publicado: (2013)

From plans to actions in patient and public involvement: qualitative study of documented plans and the accounts of researchers and patients sampled from a cohort of clinical trials
por: Buck, Deborah, et al.
Publicado: (2014)

Developing a real-time electronic symptom monitoring system for patients after discharge following cancer-related surgery
por: Avery, Kerry N. L., et al.
Publicado: (2019)

Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays
por: Kearney, Anna, et al.
Publicado: (2014)

A mixed methods approach to assess the reliability of a test for the success of blinding in a surgical randomised controlled trial (RCT)
por: Boulind, Caroline E, et al.
Publicado: (2011)

Video clinics versus standard face-to-face appointments for liver transplant patients in routine hospital outpatient care: study protocol for a pragmatic randomised evaluation of myVideoClinic
por: O’Connell Francischetto, Elaine, et al.
Publicado: (2018)

Methods for evaluating innovative surgery: a nested ideal phase 2 study within an external randomised pilot (the ROMIO trial)
por: Blazeby, Jane, et al.
Publicado: (2015)

Detailed systematic analysis of recruitment strategies in randomised controlled trials in patients with an unscheduled admission to hospital
por: Rowlands, Ceri, et al.
Publicado: (2018)

Patient and public involvement in the early stages of clinical trial development: a systematic cohort investigation
por: Gamble, Carrol, et al.
Publicado: (2014)

Managing clustering effects and learning effects in the design and analysis of randomised surgical trials: a review of existing guidance
por: Conroy, Elizabeth J., et al.
Publicado: (2022)

Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: a survey to establish current practice
por: Conroy, Elizabeth J., et al.
Publicado: (2020)

The use of systematic reviews in the design of randomised trials
por: Jones, Ashley P, et al.
Publicado: (2011)

Electronic Patient Reporting of Adverse Events and Quality of Life: A Prospective Feasibility Study in General Oncology
por: Kennedy, Fiona, et al.
Publicado: (2021)

Pragmatic approaches to mitigating missing data and research priorities to assess the effectiveness of interventions
por: Kearney, Anna, et al.
Publicado: (2015)

A review of the description of patient withdrawal in trial protocols and patient information sheets (PIS)
por: Kearney, Anna, et al.
Publicado: (2015)

“To have, to hold, from this day forward”: understanding current practice regarding the retention of trial participants
por: Daykin, Anne, et al.
Publicado: (2015)

The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials
por: Jones, Ashley, et al.
Publicado: (2013)

Compassionate care intervention for hospital nursing teams caring for older people: a pilot cluster randomised controlled trial
por: Gould, Lisa Jane, et al.
Publicado: (2018)

Reporting of clinical trials: a review of research funders' guidelines
por: Dwan, Kerry, et al.
Publicado: (2008)

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias — An Updated Review
por: Dwan, Kerry, et al.
Publicado: (2013)

STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain
por: Bishop, Annette, et al.
Publicado: (2017)

Discharge interventions for older patients leaving hospital: protocol for a systematic meta-review
por: O’Connell Francischetto, Elaine, et al.
Publicado: (2016)

Identifying research priorities for effective retention strategies in clinical trials
por: Kearney, Anna, et al.
Publicado: (2017)

Increasing chlamydia screening tests in general practice: a modified Zelen prospective Cluster Randomised Controlled Trial evaluating a complex intervention based on the Theory of Planned Behaviour
por: McNulty, Cliodna A M, et al.
Publicado: (2014)

Acute hospital-based services utilisation during the last year of life in New South Wales, Australia: methods for a population-based study
por: O'Connell, Dianne L, et al.
Publicado: (2014)

The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials
por: Jones, Ashley P, et al.
Publicado: (2013)

Application and investigation of a bound for outcome reporting bias
por: Williamson, Paula R, et al.
Publicado: (2007)

Reported reasons for missing data and the interplay with trial setting
por: Kearney, Anna, et al.
Publicado: (2015)

A mapping and gapping analysis of patient and public involvement in a clinical trials unit
por: Bagley, Heather, et al.
Publicado: (2013)

Pharmacist and Homeless Outreach Engagement and Non-medical Independent prescribing Rx (PHOENIx): a study protocol for a pilot randomised controlled trial
por: Lowrie, Richard, et al.
Publicado: (2022)

Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials
por: McKay, Andrew J., et al.
Publicado: (2021)

What is the effect of patient-reported outcome (PRO) item order on prioritisation of PROs in the development of a core outcome set?
por: Chalmers, Katy, et al.
Publicado: (2015)

The importance of stakeholder selection in core outcome set development: how surveying different health professionals may influence outcome selection
por: Avery, Kerry, et al.
Publicado: (2015)

Value of surgical pilot and feasibility study protocols
por: Fairhurst, K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_696duhgvkqp0j76ga6qk4g63j1