The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8(+) T Cells Present in the Liver

Since the demonstration of sterile protection afforded by injection of irradiated sporozoites, CD8(+) T cells have been shown to play a significant role in protection from liver-stage malaria. This is, however, dependent on the presence of an extremely high number of circulating effector cells, thou...

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Detalles Bibliográficos
Autores principales: Spencer, Alexandra J., Longley, Rhea J., Gola, Anita, Ulaszewska, Marta, Lambe, Teresa, Hill, Adrian V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2017
Materias:
Infectious Disease and Host Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318841/
https://www.ncbi.nlm.nih.gov/pubmed/28087668
http://dx.doi.org/10.4049/jimmunol.1601209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318841/
https://www.ncbi.nlm.nih.gov/pubmed/28087668
http://dx.doi.org/10.4049/jimmunol.1601209

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