Cargando…

The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8(+) T Cells Present in the Liver

Since the demonstration of sterile protection afforded by injection of irradiated sporozoites, CD8(+) T cells have been shown to play a significant role in protection from liver-stage malaria. This is, however, dependent on the presence of an extremely high number of circulating effector cells, thou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spencer, Alexandra J., Longley, Rhea J., Gola, Anita, Ulaszewska, Marta, Lambe, Teresa, Hill, Adrian V. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2017
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318841/ https://www.ncbi.nlm.nih.gov/pubmed/28087668 http://dx.doi.org/10.4049/jimmunol.1601209

Ejemplares similares

Protection from liver-stage malaria is dependent on a fine balance between the number of infected hepatocytes and effector CD8(+) T cells
por: Spencer, Alexandra, et al.
Publicado: (2014)

Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
por: Naluyima, Prossy, et al.
Publicado: (2019)

Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages
por: McNab, Finlay W., et al.
Publicado: (2014)

MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus
por: Reynolds, Lisa A., et al.
Publicado: (2014)

CD4(+) T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria
por: Gitau, Evelyn N., et al.
Publicado: (2014)

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis
por: Reynolds, Catherine, et al.
Publicado: (2015)

Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children
por: Muema, Daniel M., et al.
Publicado: (2015)

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans
por: Currie, Silke M., et al.
Publicado: (2016)

Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome
por: Wilkinson, Katalin A., et al.
Publicado: (2015)

The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4(+) T Cell Responses
por: Pachnio, Annette, et al.
Publicado: (2015)

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism
por: Whibley, Natasha, et al.
Publicado: (2015)

PI3Kδ Regulates the Magnitude of CD8(+) T Cell Responses after Challenge with Listeria monocytogenes
por: Pearce, Verity Q., et al.
Publicado: (2015)

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding
por: Lennartz, Frank, et al.
Publicado: (2015)

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2016)

Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
por: Mavrommatis, Bettina, et al.
Publicado: (2016)

Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α(+) Dendritic Cells at the Site of Infection
por: Napolitano, Anna, et al.
Publicado: (2018)

Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages
por: Lim, Jenson, et al.
Publicado: (2018)

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity
por: Lindau, Paul, et al.
Publicado: (2019)

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish
por: Ogryzko, Nikolay V., et al.
Publicado: (2019)

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4(+) T Cells
por: Meckiff, Benjamin J., et al.
Publicado: (2019)

Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells
por: Singh, Randeep, et al.
Publicado: (2017)

T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2017)

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance
por: Patin, Emmanuel C., et al.
Publicado: (2016)

Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection
por: Brilha, Sara, et al.
Publicado: (2017)

A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP
por: Goldblatt, Jennifer, et al.
Publicado: (2019)

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
por: Villegas-Mendez, Ana, et al.
Publicado: (2020)

Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain Salmonella
por: Perez-Toledo, Marisol, et al.
Publicado: (2020)

Stochastic Expansions Maintain the Clonal Stability of CD8(+) T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus
por: Smith, Corinne J., et al.
Publicado: (2020)

Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance
por: Thofte, Oskar, et al.
Publicado: (2021)

Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node
por: Aggio, Juliana Bernardi, et al.
Publicado: (2021)

Cyclooxygenase-Derived Prostaglandin E(2) Drives IL-1–Independent Mycobacterium bovis Bacille Calmette-Guérin–Triggered Skin Dendritic Cell Migration to Draining Lymph Node
por: Krmeská, Veronika, et al.
Publicado: (2022)

Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis
por: Dow, Joshua, et al.
Publicado: (2023)

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation
por: Roberts, Joseph, et al.
Publicado: (2023)

Recruitment of Neutrophils Mediated by Vγ2 γδ T Cells Deteriorates Liver Fibrosis Induced by Schistosoma japonicum Infection in C57BL/6 Mice
por: Zheng, Li, et al.
Publicado: (2017)

OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection
por: Manam, Srikanth, et al.
Publicado: (2013)

Streptococcus mitis Abscesses Mimicking Liver Metastases
por: Elnaggar, Mohamed, et al.
Publicado: (2020)

Enterovirus-Induced Severe Rhabdomyolysis and Acute Fulminant Liver Failure in an Immunocompetent Adult Requiring Liver Transplantation: A Case Report
por: Angappan, Santhalakshmi, et al.
Publicado: (2022)

Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata
por: Ifrim, Daniela C., et al.
Publicado: (2014)

Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells
por: Guenot, Marianne, et al.
Publicado: (2015)

Intestinal Epithelial Toll-Like Receptor 4 Signaling Affects Epithelial Function and Colonic Microbiota and Promotes a Risk for Transmissible Colitis
por: Dheer, Rishu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_e5nf6d2aatgj9aspjqgn7ui85j