Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

Ethyl pyruvate (EP) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions. In an effort to develop novel EP derivatives with greater protective potencies than EP, we generated four...

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Detalles Bibliográficos
Autores principales: Lee, Hye-Kyung, Kim, Il-Doo, Kim, Seung-Woo, Lee, Hahnbie, Park, Ju-Young, Yoon, Sung-Hwa, Lee, Ja-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318887/
https://www.ncbi.nlm.nih.gov/pubmed/28220827
http://dx.doi.org/10.1038/srep42891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318887/
https://www.ncbi.nlm.nih.gov/pubmed/28220827
http://dx.doi.org/10.1038/srep42891

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