Cargando…

Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

Ethyl pyruvate (EP) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions. In an effort to develop novel EP derivatives with greater protective potencies than EP, we generated four...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hye-Kyung, Kim, Il-Doo, Kim, Seung-Woo, Lee, Hahnbie, Park, Ju-Young, Yoon, Sung-Hwa, Lee, Ja-Kyeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318887/ https://www.ncbi.nlm.nih.gov/pubmed/28220827 http://dx.doi.org/10.1038/srep42891

Ejemplares similares

Gastrodin exerts robust neuroprotection in the postischemic brain via its protective effect against Zn(2+)-toxicity and its anti-oxidative effects in astrocytes
por: Luo, Lidan, et al.
Publicado: (2018)

Robust neuroprotective effects of 2-((2-oxopropanoyl)oxy)-4-(trifluoromethyl)benzoic acid (OPTBA), a HTB/pyruvate ester, in the postischemic rat brain
por: Kim, Seung-Woo, et al.
Publicado: (2016)

Proangiogenic functions of an RGD-SLAY-containing osteopontin icosamer peptide in HUVECs and in the postischemic brain
por: Lee, Hahnbie, et al.
Publicado: (2018)

Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain
por: Kim, Seung-Woo, et al.
Publicado: (2020)

The use of Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, in robust neuroprotection in the postischemic brain
por: Kim, Seung-Woo, et al.
Publicado: (2011)

Creatine Protects against Excitoxicity in an In Vitro Model of Neurodegeneration
por: Genius, Just, et al.
Publicado: (2012)

Reducing excitoxicity with glutamate transporter-1 to treat stroke
por: Wang, Yun, et al.
Publicado: (2016)

Neuroprotective effect of masitinib in rats with postischemic stroke
por: Kocic, Ivan, et al.
Publicado: (2014)

Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners
por: Luo, Lidan, et al.
Publicado: (2017)

Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa
por: Brencher, Lisa, et al.
Publicado: (2017)

Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathy
por: RONG, ZHIHUI, et al.
Publicado: (2015)

3-Diazo-N-[(2S)-1-hydroxypropan-2-yl]-2-oxopropanamide
por: Chen, Xiao-na, et al.
Publicado: (2011)

Neuroprotective effects of tannic acid in the postischemic brain via direct chelation of Zn(2+)
por: Kim, Seung Woo, et al.
Publicado: (2022)

Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
por: Wang, Chen, et al.
Publicado: (2021)

Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides
por: Dahlgren, Markus K., et al.
Publicado: (2010)

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations
por: Fernández-Serra, Rocío, et al.
Publicado: (2022)

Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms
por: Debebe, Tewodros, et al.
Publicado: (2016)

Pro/Anti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling
por: Anna Laura, Pasqui, et al.
Publicado: (2010)

Taurine Protects against Postischemic Brain Injury via the Antioxidant Activity of Taurine Chloramine
por: Seol, Song-I, et al.
Publicado: (2021)

Energy-entropy prediction of octanol–water logP of SAMPL7 N-acyl sulfonamide bioisosters
por: Falcioni, Fabio, et al.
Publicado: (2021)

Osteopontin Peptide Icosamer Containing RGD and SLAYGLR Motifs Enhances the Motility and Phagocytic Activity of Microglia
por: Kim, Il-Doo, et al.
Publicado: (2017)

Erratum to “Pro/Anti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling”
por: Pasqui, Anna Laura, et al.
Publicado: (2010)

Ethyl Acetate Fractions of Papaver rhoeas L. and Papaver nudicaule L. Exert Antioxidant and Anti-Inflammatory Activities
por: Kim, Hail, et al.
Publicado: (2021)

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain
por: Kim, Seung-Woo, et al.
Publicado: (2019)

Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
por: Jang, In-Seok, et al.
Publicado: (2010)

Endoplasmic Reticulum Stress Mediates the Anti-Inflammatory Effect of Ethyl Pyruvate in Endothelial Cells
por: Wang, Ge, et al.
Publicado: (2014)

CD200 Change Is Involved in Neuronal Death in Gerbil Hippocampal CA1 Field Following Transient Forebrain Ischemia and Postischemic Treatment with Risperidone Displays Neuroprotection without CD200 Change
por: Lee, Tae-Kyeong, et al.
Publicado: (2021)

HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain
por: Davaanyam, Dashdulam, et al.
Publicado: (2023)

Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats
por: Kim, Junghyun, et al.
Publicado: (2013)

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation
por: Chen, I-Cheng, et al.
Publicado: (2018)

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
por: Yang, Runkuan, et al.
Publicado: (2016)

Involvement of Lactate and Pyruvate in the Anti-Inflammatory Effects Exerted by Voluntary Activation of the Sympathetic Nervous System
por: Zwaag, Jelle, et al.
Publicado: (2020)

Postischemic Inflammation in Acute Stroke
por: Vidale, Simone, et al.
Publicado: (2017)

Transthyretin expression in the postischemic brain
por: Talhada, Daniela, et al.
Publicado: (2019)

Glutamate Excitoxicity Is the Key Molecular Mechanism Which Is Influenced by Body Temperature during the Acute Phase of Brain Stroke
por: Campos, Francisco, et al.
Publicado: (2012)

Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression
por: Lee, Yun Mi, et al.
Publicado: (2013)

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin
por: Harder, Jeffrey M., et al.
Publicado: (2020)

A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects
por: Lee, Ji Ae, et al.
Publicado: (2022)

MicroRNAs in Postischemic Vascular Repair
por: Caporali, Andrea, et al.
Publicado: (2012)

Correction: Transthyretin expression in the postischemic brain
por: Talhada, Daniela, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tsosdpg264ufs4m51lviskmua9