Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM

In the mammalian brain the ubiquitous tyrosine kinase, C-Src, undergoes splicing to insert short sequences in the SH3 domain to yield N1- and N2-Src. We and others have previously shown that the N-Srcs have altered substrate specificity and kinase activity compared to C-Src. However, the exact funct...

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Detalles Bibliográficos
Autores principales: Keenan, Sarah, Wetherill, Sarah J., Ugbode, Christopher I., Chawla, Sangeeta, Brackenbury, William J., Evans, Gareth J. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318895/
https://www.ncbi.nlm.nih.gov/pubmed/28220894
http://dx.doi.org/10.1038/srep43106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318895/
https://www.ncbi.nlm.nih.gov/pubmed/28220894
http://dx.doi.org/10.1038/srep43106

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