A computational protocol to evaluate the effects of protein mutants in the kinase gatekeeper position on the binding of ATP substrate analogues

BACKGROUND: The determination of specific kinase substrates in vivo is challenging due to the large number of protein kinases in cells, their substrate specificity overlap, and the lack of highly specific inhibitors. In the late 90s, Shokat and coworkers developed a protein engineering-based method...

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Detalles Bibliográficos
Autores principales: Romano, Valentina, de Beer, Tjaart A. P., Schwede, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319021/
https://www.ncbi.nlm.nih.gov/pubmed/28219448
http://dx.doi.org/10.1186/s13104-017-2428-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319021/
https://www.ncbi.nlm.nih.gov/pubmed/28219448
http://dx.doi.org/10.1186/s13104-017-2428-9

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