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Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes

In the central nervous system, viral infection can induce inflammation by up-regulating pro-inflammatory mediators that contribute to enhanced infiltration of immune cells into the central nervous areas. Celastrol is known to exert various regulatory functions, including anti-microbial activities. I...

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Detalles Bibliográficos
Autores principales: An, Soo Yeon, Youn, Gi Soo, Kim, Hyejin, Choi, Soo Young, Park, Jinseu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319661/
https://www.ncbi.nlm.nih.gov/pubmed/28027722
http://dx.doi.org/10.5483/BMBRep.2017.50.1.114