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Vitamin C enhances the expression of IL17 in a Jmjd2–dependent manner

Previously, we reported that vitamin C facilitates the CpG demethylation of Foxp3 enhancer in CD4(+)Foxp3(+) regulatory T cells (Tregs) by enhancing the activity of a DNA demethylase ten-eleven-translocation (Tet). However, it is not clear whether vitamin C affects other helper T cell lineages like...

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Detalles Bibliográficos
Autores principales: Song, Mi Hye, Nair, Varun Sasidharan, Oh, Kwon Ik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319665/
https://www.ncbi.nlm.nih.gov/pubmed/27931518
http://dx.doi.org/10.5483/BMBRep.2017.50.1.193