Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors

Alterations in protein glycosylation are a key feature of oncogenesis and have been shown to affect cancer cell behaviour perturbing cell adhesion, favouring cell migration and metastasis. This study investigated the effect of N-linked glycosylation on the binding of Herceptin to HER2 protein in bre...

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Detalles Bibliográficos
Autores principales: Peiris, Diluka, Spector, Alexander F., Lomax-Browne, Hannah, Azimi, Tayebeh, Ramesh, Bala, Loizidou, Marilena, Welch, Hazel, Dwek, Miriam V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320443/
https://www.ncbi.nlm.nih.gov/pubmed/28223691
http://dx.doi.org/10.1038/srep43006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320443/
https://www.ncbi.nlm.nih.gov/pubmed/28223691
http://dx.doi.org/10.1038/srep43006

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