Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

CD4+FOXP3+ Treg are essential for immune tolerance. Phase-1 clinical trials of Treg-therapy to treat graft-versus-host-disease reported safety and potential therapeutic efficacy. Treg-based trials have started in organ-transplant patients. However, efficient ex vivo expansion of a stable Treg popula...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xuehui, Smeets, Ruben L., van Rijssen, Esther, Boots, Annemieke M. H., Joosten, Irma, Koenen, Hans J. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320448/
https://www.ncbi.nlm.nih.gov/pubmed/28223693
http://dx.doi.org/10.1038/srep43003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320448/
https://www.ncbi.nlm.nih.gov/pubmed/28223693
http://dx.doi.org/10.1038/srep43003

Ejemplares similares