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Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

CD4+FOXP3+ Treg are essential for immune tolerance. Phase-1 clinical trials of Treg-therapy to treat graft-versus-host-disease reported safety and potential therapeutic efficacy. Treg-based trials have started in organ-transplant patients. However, efficient ex vivo expansion of a stable Treg popula...

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Detalles Bibliográficos
Autores principales:	He, Xuehui, Smeets, Ruben L., van Rijssen, Esther, Boots, Annemieke M. H., Joosten, Irma, Koenen, Hans J. P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320448/ https://www.ncbi.nlm.nih.gov/pubmed/28223693 http://dx.doi.org/10.1038/srep43003

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