4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities

Interactions between calcium-activated chloride channel anoctamin 1 (ANO1) and transient receptor potential vanilloid 1 (TRPV1) enhance pain sensations in mice, suggesting that ANO1 inhibition could have analgesic effects. Here we show that menthol and the menthol analogue isopropylcyclohexane (iPr-...

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Detalles Bibliográficos
Autores principales: Takayama, Yasunori, Furue, Hidemasa, Tominaga, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320485/
https://www.ncbi.nlm.nih.gov/pubmed/28225032
http://dx.doi.org/10.1038/srep43132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320485/
https://www.ncbi.nlm.nih.gov/pubmed/28225032
http://dx.doi.org/10.1038/srep43132

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