Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (Na(V)), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of the most potent congener, Pacific ciguatoxi...

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Detalles Bibliográficos
Autores principales: Inserra, Marco C., Israel, Mathilde R., Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmermann, Katharina, Lewis, Richard J., Brierley, Stuart M., Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320492/
https://www.ncbi.nlm.nih.gov/pubmed/28225079
http://dx.doi.org/10.1038/srep42810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320492/
https://www.ncbi.nlm.nih.gov/pubmed/28225079
http://dx.doi.org/10.1038/srep42810

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