Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

Epigenetic and transcriptional alterations are both implicated in Huntington’s disease (HD), a progressive neurodegenerative disease resulting in degeneration of striatal neurons in the brain. However, how impaired epigenetic regulation leads to transcriptional dysregulation in HD is unclear. Here,...

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Detalles Bibliográficos
Autores principales: Le Gras, Stéphanie, Keime, Céline, Anthony, Anne, Lotz, Caroline, De Longprez, Lucie, Brouillet, Emmanuel, Cassel, Jean-Christophe, Boutillier, Anne-Laurence, Merienne, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320509/
https://www.ncbi.nlm.nih.gov/pubmed/28225006
http://dx.doi.org/10.1038/srep42875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320509/
https://www.ncbi.nlm.nih.gov/pubmed/28225006
http://dx.doi.org/10.1038/srep42875

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