EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux

OBJECTIVE—: The sterol-responsive nuclear receptors, liver X receptors α (LXRα, NR1H3) and β (LXRβ, NR1H2), are key determinants of cellular cholesterol homeostasis. LXRs are activated under conditions of high cellular sterol load and induce expression of the cholesterol efflux transporters ABCA1 an...

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Detalles Bibliográficos
Autores principales: Nelson, Jessica Kristine, Koenis, Duco Steven, Scheij, Saskia, Cook, Emma Clare Laura, Moeton, Martina, Santos, Ana, Lobaccaro, Jean-Marc Adolphe, Baron, Silvere, Zelcer, Noam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321112/
https://www.ncbi.nlm.nih.gov/pubmed/28082258
http://dx.doi.org/10.1161/ATVBAHA.116.308434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321112/
https://www.ncbi.nlm.nih.gov/pubmed/28082258
http://dx.doi.org/10.1161/ATVBAHA.116.308434

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