Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey

SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the expression of genes involved in fatty acid and choles...

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Detalles Bibliográficos
Autores principales: Jensen, Kristian K., Tadin-Strapps, Marija, Wang, Sheng-ping, Hubert, James, Kan, Yanqing, Ma, Yong, McLaren, David G., Previs, Stephen F., Herath, Kithsiri B., Mahsut, Ablatt, Liaw, Andy, Wang, Shubing, Stout, Steven J., Keohan, CarolAnn, Forrest, Gail, Coelho, David, Yendluri, Satya, Williams, Stephanie, Koser, Martin, Bartz, Steven, Akinsanya, Karen O., Pinto, Shirly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321219/
https://www.ncbi.nlm.nih.gov/pubmed/27707816
http://dx.doi.org/10.1194/jlr.M071498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321219/
https://www.ncbi.nlm.nih.gov/pubmed/27707816
http://dx.doi.org/10.1194/jlr.M071498

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