A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing

Mitogen activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions, and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and co-ordinate simultaneous Erk, Jnk and p38 MAPK activation in T lymphocyte...

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Detalles Bibliográficos
Autores principales: Lanna, Alessio, Gomes, Daniel C O, Muller-Durovic, Bojana, McDonnell, Thomas, Escors, David, Gilroy, Derek W, Lee, Jun Hee, Karin, Michael, Akbar, Arne N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321575/
https://www.ncbi.nlm.nih.gov/pubmed/28114291
http://dx.doi.org/10.1038/ni.3665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321575/
https://www.ncbi.nlm.nih.gov/pubmed/28114291
http://dx.doi.org/10.1038/ni.3665

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