Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Aggregation of hypertrophic macrophages constitutes the basis of all granulomatous diseases such as tuberculosis or sarcoidosis and is decisive for disease pathogenesis. However, macrophage-intrinsic pathways driving granuloma initiation and maintenance remain elusive. Here we show that activation o...

Descripción completa

Detalles Bibliográficos
Autores principales: Linke, Monika, Pham, Ha Thi Thanh, Katholnig, Karl, Schnöller, Thomas, Miller, Anne, Demel, Florian, Schütz, Birgit, Rosner, Margit, Kovacic, Boris, Sukhbaatar, Nyamdelger, Niederreiter, Birgit, Blüml, Stephan, Kuess, Peter, Sexl, Veronika, Müller, Mathias, Mikula, Mario, Weckwerth, Wolfram, Haschemi, Arvand, Susani, Martin, Hengstschläger, Markus, Gambello, Michael J, Weichhart, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321578/
https://www.ncbi.nlm.nih.gov/pubmed/28092373
http://dx.doi.org/10.1038/ni.3655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321578/
https://www.ncbi.nlm.nih.gov/pubmed/28092373
http://dx.doi.org/10.1038/ni.3655

Ejemplares similares