Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expres...

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Detalles Bibliográficos
Autores principales: Chen, Huixian, Mao, Ruoyu, Teng, Da, Wang, Xiumin, Hao, Ya, Feng, Xingjun, Wang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321639/
https://www.ncbi.nlm.nih.gov/pubmed/28229435
http://dx.doi.org/10.1186/s13568-017-0345-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321639/
https://www.ncbi.nlm.nih.gov/pubmed/28229435
http://dx.doi.org/10.1186/s13568-017-0345-x

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