SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

Coordination between osteoblasts and osteoclasts is required for bone health and homeostasis. Here we show that mice deficient in SMURF2 have severe osteoporosis in vivo. This low bone mass phenotype is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclasts...

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Detalles Bibliográficos
Autores principales: Xu, Zhan, Greenblatt, Matthew B., Yan, Guang, Feng, Heng, Sun, Jun, Lotinun, Sutada, Brady, Nicholas, Baron, Roland, Glimcher, Laurie H., Zou, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321737/
https://www.ncbi.nlm.nih.gov/pubmed/28216630
http://dx.doi.org/10.1038/ncomms14570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321737/
https://www.ncbi.nlm.nih.gov/pubmed/28216630
http://dx.doi.org/10.1038/ncomms14570

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